Imiquimod comes as a cream to apply to the skin. If you are using imiquimod cream to treat actinic keratoses, you will probably apply it once a day for 2 days a week, 3 to 4 days apart (e.g., Monday and Thursday or Tuesday and Friday). Overall, in the clinical trials, 11% (17/160) of subjects in the Imiquimod Cream, 3.75% arm, 7% (11/160) of subjects in the Imiquimod Cream, 2.5% arm, and 0% in the vehicle cream arm required rest periods due to adverse local skin reactions. The 5% imiquimod cream is licensed for the treatment of sun damage in the form of superficial pre-cancerous (actinic keratoses) and low grade cancerous skin conditions (superficial basal cell carcinoma). Imiquimod 5 cream comes in the form of a cream for skin application. If you use the drug for the treatment of AK, you should apply it once a day for two days a week. Avoid applying the cream the mouth, nose and eyes. Apply imiquimod cream for 6 weeks, 5 times per week (example: Monday to Friday) prior to normal sleeping hours, and leave on the skin for approximately 8 hours. For quantity to be applied see 4.2 Method of administration. Read carefully the directions you are given for using imiquimod cream. If you are unsure how many times a week to apply the cream, ask your pharmacist to check for you. Adults—Apply a thin film to the affected area of skin once a day at bedtime 5 times per week for 6 weeks. Your doctor will tell you which days are best during the week. Your doctor will tell you which days are best during the week. Easy-to-read patient leaflet for Imiquimod Cream (Aldara). Includes indications, proper use, special instructions, precautions, and possible side effects. Includes indications, proper use, special instructions, precautions, and possible side effects. When treating superficial basal cell carcinoma, apply 5 times a week for a full 6 weeks. imiquimod 5 % topical cream packet. imiquimod 5 % topical cream packet. color white shape No data. I have had genital warts for over a year. I have been using Imiquimod cream for about 2 months now. Most or all of the warts have disappeared. Toward the end of the treatment, however, one area of my penis became very red and the middle part of the red area has started to scab (see included picture).